The TTL Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to TTLL6. This antibody recognizes Human, Mouse, and Rat antigen. The TTL Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Function: Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS.
Subunit Structure: Found in a complex with CEP41.
Similarity: The flexible c-MTBD (cationic microtubule binding domain) region mediates binding to microtubules. It is positively charged and becomes ordered when bound to microtubules: it interacts with a negatively charged patch on tubulin. The presence of positive charges in the c-MTBD region is essential for proper binding. Belongs to the tubulin--tyrosine ligase family